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Seeing Alzheimer's in Real Time

Audio/Video Transcript

Audio: Opening music.

Text: Seeing Alzheimer's in Real Time

Advanced Brain Imaging

Text: Adam S. Fleisher, MD, M.A.S.

Director of Brain Imaging

Image: Adam S. Fleisher, MD, on-camera

Audio: "What's really exciting in Alzheimer's disease and in imaging right now -- we've now learned how to take pictures of Alzheimer's disease itself; the pathology -- the plaques in the brain that we believe are central to developing Alzheimer's disease."

Text: Eric M. Reiman, MD

Executive Director of Banner Alzheimer's Institute

Co-leader of the Alzheimer's Prevention Initiative

Image: Eric M. Reiman, MD, on-camera

Audio: "And one of the techniques we're most excited about is the development of a new imaging technique, which I'll refer to generically as amyloid PET…"

Image: Images of brain using amyloid PET

Audio: "…that allows us to visualize those amyloid plaques that we use to diagnose Alzheimer's disease at the end of life, after somebody has died.

Image: Eric M. Reiman, MD, on-camera

Audio: "We can now evaluate that in life."

Text: Jessica Langbaum, PhD

Alzheimer's Researcher

Image: Jessica Langbaum, on-camera

Audio: "So these brain imaging measures using FDG-PET or amyloid PET are correlated with the APOE e4 gene dose and we see them before there is any memory thinking impairment. So they're picking up the disease before it turns into symptomatic dementia."

Image: Adam S. Fleisher, MD, on-camera

Audio: "So with that, for the first time…"

Text: Hallmark abnormalities are deposits of amyloid protein and twisted strands of tau protein.

Audio: "…yeah, we can actually identify whether you have evidence of the brain, of these amyloid plaques that are the essence of Alzheimer's pathology."

Text: We are now using amyloid PET and other advanced imaging techniques in our clinical trials.

Text: Banner Alzheimer's Institute